Panacea CoffeeHouse, Cafe and Roastery - Cafe in Waynesville, Tennessee
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Panacea CoffeeHouse, Cafe and Roastery

Waynesville66 Commerce St Waynesville NC 28786
9.5
Outstanding

Best For

Coffee lovers • Remote workers • Families

Pro Tip

Try the locally roasted beans and sit by the creek for the best ambiance

About Panacea CoffeeHouse, Cafe and Roastery

Located in a beautifully restored warehouse in downtown Waynesville, Panacea CoffeeHouse, Cafe and Roastery brings together the art of coffee roasting with casual cafe dining. The exposed brick walls and industrial-meets-cozy atmosphere make this a favorite spot for both locals and visitors seeking quality coffee and fresh food.

As a working roastery, Panacea offers customers the unique experience of watching small-batch coffee roasting in action while enjoying their drinks. The cafe sources high-quality beans from sustainable growers, and their skilled baristas craft everything from perfectly pulled espresso shots to carefully prepared pour-overs.

The breakfast menu features classic morning favorites like avocado toast, house-made pastries, and hearty breakfast sandwiches. For lunch, you'll find fresh salads, grilled paninis, and seasonal soups. The brick walls and wooden tables create an inviting space for working, meeting friends, or simply enjoying a quiet moment with a expertly crafted latte.

What sets Panacea apart is their commitment to the coffee community in Waynesville. They regularly host coffee education events, tasting sessions, and workshops for those interested in learning more about coffee cultivation and preparation. The knowledgeable staff is always happy to discuss their latest roasts or help you select beans to brew at home.

The cafe provides free WiFi and plenty of seating options, from communal tables to intimate corners. Whether you're stopping in for your morning coffee, meeting colleagues for lunch, or picking up freshly roasted beans, Panacea CoffeeHouse combines the precision of a serious roastery with the welcoming vibe of a neighborhood cafe.

Last updated: February 22, 2026 • Based on 709 reviews

Amenities & Features

Exceptional outdoor patio seating with creek/river viewsHouse-roasted coffee including organic Guatemala dark roast with excellent flavorVersatile atmosphere perfect for studying, business meetings, or casual hangoutsPopular food items including wraps and the Wakey Wakey breakfast sandwich on sourdough

Opening Hours

Monday8:30 AM to 3:30 PM
Tuesday8:30 AM to 3:30 PM
Wednesday8:30 AM to 3:30 PM
Thursday8:30 AM to 3:30 PM
Friday8:30 AM to 3:30 PM
Saturday8:30 AM to 3:30 PM
Sunday8:30 AM to 3:30 PM

Best Times to Visit Panacea CoffeeHouse, Cafe and Roastery

For the best dining experience, consider making reservations for weekend evenings.

🔥Buzzing
Weekend dinner rush 5PM - 8PM
☀️Relaxed
Tuesday & Wednesday evenings

Tags

Highly Reviewed

Frequently Asked Questions

What are the hours for Panacea CoffeeHouse, Cafe and Roastery?

Check our opening hours section for current times. Hours may vary seasonally.

Is Panacea CoffeeHouse, Cafe and Roastery family-friendly?

Yes, Panacea CoffeeHouse, Cafe and Roastery welcomes visitors of all ages. It's a popular destination for families visiting Waynesville.

How do I get to Panacea CoffeeHouse, Cafe and Roastery?

Panacea CoffeeHouse, Cafe and Roastery is located at 66 Commerce St Waynesville NC 28786. Use the directions button for navigation.

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